Wearable and ingestible medical devices hold profound implications in medicine, supporting a new generation of personalized and automated therapies with higher patient compliance and faster diagnostic feedback. In this class, we will explore a series of technologies that physically interact with targeted tissues through programmable geometric and material transformations to enable previously unachievable therapeutic and sensing capabilities. We will also explore how design thinking strategies and health decision analyses are utilized to develop new devices that provide quantitative improvements to patients' quality of life. The class will culminate with debate-style presentations where students discuss the merits of new innovations such as vaccine patches and wearable sweat sensors over the standard-of-care.